Search results for "Insulin-Like Growth Factor Binding Protein 2"

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Elevated serum levels of IGF-binding protein 2 in patients with non-seminomatous germ cell cancer: correlation with tumor markers alpha-fetoprotein a…

2008

Background/aimsAlterations of the IGF system have been described in several different types of cancer. However, no information is available about the role of the IGF system in patients with non-seminomatous germ cell cancer.MethodsFree IGF-I, IGF-II, acid-labile subunit, and IGF-binding proteins (IGFBPs) 1–4 were analyzed by specific RIAs in 32 patients with untreated non-seminomas and compared with IGFBP levels of 38 healthy controls. Serum IGFBPs were analyzed by western ligand blotting (WLB) and immunoblotting. In 16 patients, IGFBP profiles were measured before, during, and after treatment.ResultsIn patients with testicular cancer, IGF-II levels were on average 1.44-fold higher than in …

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismProtein subunitBiologyChorionic GonadotropinInsulin-like growth factor-binding proteinHuman chorionic gonadotropinEndocrinologyTesticular NeoplasmsInsulin-Like Growth Factor IIRecurrenceInternal medicinemedicineBiomarkers TumorHumansIn patientTesticular cancerBinding proteinCancerGeneral MedicineMiddle AgedNeoplasms Germ Cell and Embryonalmedicine.diseaseUp-RegulationInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor Binding Protein 2EndocrinologyInsulin-Like Growth Factor Binding Protein 3Case-Control Studiesbiology.proteinalpha-FetoproteinsOncofetal antigenProtein Processing Post-TranslationalEuropean journal of endocrinology
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Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.

2004

Clinically silent adrenocortical adenomas are the most frequent abnormalities in the adrenal gland. In contrast, adrenocortical carcinoma is a rare tumor with an extremely poor prognosis. The factors responsible for the frequent occurrence of benign adrenocortical tumors on one hand and the rare malignant transformation on the other are not known. Several genetic alterations such as loss of imprinting or loss of heterozygosity of the 11p15 gene locus causing a strong IGF-II overexpression have been demonstrated in the majority of adrenocortical carcinomas. In addition to IGF-II overexpression, increased levels of the IGF-I-receptor and IGFBP-2 have been found in advanced human adrenocortica…

Genetically modified mousemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryAdrenal Gland NeoplasmsLoss of HeterozygosityBiologymedicine.disease_causeBiochemistryMalignant transformationReceptor IGF Type 1Loss of heterozygosityInsulin-like growth factorMiceEndocrinologyInsulin-Like Growth Factor IIInternal medicineCell Line TumormedicineAdrenocortical carcinomaAnimalsHumansNeoplastic transformationNeoplastic ProcessesAdrenal glandChromosomes Human Pair 11Biochemistry (medical)CarcinomaGeneral Medicinemedicine.diseaseGene Expression Regulation NeoplasticInsulin-Like Growth Factor Binding Protein 2medicine.anatomical_structureEndocrinologyCarcinogenesisSignal TransductionHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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